脑活素对新生大鼠缺氧缺血性脑损伤的影响

用结扎颈动脉和缺氧的方法建立一侧缺氧缺血性脑损伤(HIE)动物模型,观察脑活素对HIE大鼠脑组织损伤的治疗作用。结果发现,缺氧缺血后新生大鼠脑组织血栓素B2(TXB2)和6酮--前列腺素F1α(6-keto-PGF1α)含量、细胞凋亡数及对侧脑组织含水量均显著升高,表明新生大鼠缺氧缺血性脑损伤与脑血流改变、脑细胞凋亡及脑组织含水量的变化密切相关;缺氧缺血大鼠应用脑活素治疗后,其脑组织TXB2和6-keto-PGF1α含量、细胞凋亡数及脑组织含水量均下降,表明脑活素通过改善脑血流、降低脑细胞凋亡及脑水肿程度来减轻缺氧缺血造成的损伤,对新生大鼠缺氧缺血性脑损伤发挥有效的治疗作用。

Effects of cerebrolysin on hypoxic-ischemic encephalopathy

To measure the effect of cerebrolysin on damages of brain tissues in newborn rat,the hypoxic-ischemic encephalopathy(HIE) model was established.The result showed that the content of thromboxane B_2(TXB_2) and 6-keto-prostaglandin F_(1α)(6-keto-PGF_(1α)),the number of apoptosis cell and the content of water increased significantly in brain tissue of hypoxic-ischemic newborn rats as compared with those of control groups,indicating that the changes of brain blood,apoptosis and in brain edema participated in brain damages of hypoxic-ischemic encephalopathy in newborn rat.After the treatment with cerebrolysin,the content of TXB_2 and 6-keto-PGF_(1α),the number of apoptosis cell and the content of water decreased as compared with those of HIE group.The results indicated that cerebrolysin had treatment effects on hypoxic-ischemic encephalopathy in newborn rat by improving brain blood,reducing number of apoptosis cell and brain edema.