宏基因组学揭示瘤胃微生物多样性及功能

反刍动物瘤胃内栖息着庞大和复杂的微生物群体,这些微生物与宿主的消化吸收、营养代谢和免疫功能息息相关,宿主及其微生物共同组成了一个"超级生物体"。由于绝大部分瘤胃微生物不可培养,因此以厌氧培养为基础的传统研究方法存在明显的弊端。宏基因组学通过高通量的测序方法,能够全面展示微生物多样性,准确发现新的功能基因。此外,宏基因组学揭示了宿主基因和微生物组之间的互作关系。随着组学技术的不断发展,宏基因组学在瘤胃微生物组研究方面具有广阔的应用前景。

Metagenomics Reveals Rumen Microbial Diversity and Functions

There are a large number of microorganisms that inhabit the rumen of ruminant animals, which are closely related to host digestion, absorption and immunization. The host and symbiotic microorganisms together constitute a "superorganisms". Because most of microorganisms in the rumen cannot be cultivated, traditional culture?dependent methods have obvious drawbacks. Metagenomics is a high throughput method that characteri?zes the rumen microbial community structure and identifies novel functional genes. Moreover, the interactions between microbiome and host genetics are also determined through the use of metagenomics. With advances in omic technologies, metagenomics can be a powerful tool in studying the rumen microbiome with encouraging prospects.