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Genetic variation in coumarin hydroxylase activity in the mouse (Mus musculus) |
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| Authors: | A W Wood A H Conney |
| Abstract: | Basal and phenobarbital-induced rates of hepatic metabolism of coumarin to 7-hydroxycoumarin are markedly higher in DBA/2J mice than they are in the AKR/J, C57BL/6J, and C3H/HeJ strains. Intermediate coumarin hydroxylase activity in F(1) hybrids of mating between DBA/2J and the other three strains indicates an additive mode of inheritance. |
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