Characterization of two key molecules of teleost innate immunity from rainbow trout (Oncorhynchus mykiss): MyD88 and SAA |
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Authors: | Alexander Rebl Tom Goldammer Uwe Fischer Bernd Kllner Hans-Martin Seyfert |
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Institution: | aResearch Institute for the Biology of Farm Animals (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany;bFriedrich-Loeffler-Institute (FLI), Federal Research Institute for Animal Health, Institute of Infectiology, Am Südufer 10, 17493 Greifswald-Insel Riems, Germany |
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Abstract: | Toll-like receptors (TLR) are relevant for piscine innate immunity. TLR activation recruits several downstream factors regulating the expression of immunorelevant genes. We have characterized two key factors of innate immunity from rainbow trout: MyD88 as an adaptor protein interacting directly with TLRs, and serum amyloid A as an effector molecule induced by the activated Toll-like receptor signaling cascade.Both factors share a remarkable high degree of structural conservation with their mammalian orthologs suggesting that innate immune defense mechanisms may also functionally be conserved between fish and mammals. |
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Keywords: | Pathogen Acute-phase protein Toll-like receptor TIR domain |
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