Salmonella modulates vesicular traffic by altering phosphoinositide metabolism |
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Authors: | Hernandez Lorraine D Hueffer Karsten Wenk Markus R Galán Jorge E |
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Institution: | Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA. |
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Abstract: | Salmonella enterica, the cause of food poisoning and typhoid fever, induces actin cytoskeleton rearrangements and membrane ruffling to gain access into nonphagocytic cells, where it can replicate and avoid innate immune defenses. Here, we found that SopB, a phosphoinositide phosphatase that is delivered into host cells by a type III secretion system, was essential for the establishment of Salmonella's intracellular replicative niche. SopB mediated the formation of spacious phagosomes following bacterial entry and was responsible for maintaining high levels of phosphatidylinositol-three-phosphate PtdIns(3)P] in the membrane of the bacteria-containing vacuoles. Absence of SopB caused a significant defect in the maturation of the Salmonella-containing vacuole and impaired bacterial intracellular growth. |
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