Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin |
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Authors: | Eggert U S Ruiz N Falcone B V Branstrom A A Goldman R C Silhavy T J Kahne D |
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Institution: | Department of Chemistry, Princeton University, Princeton, NJ 08544, USA. |
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Abstract: | Small molecules that affect specific protein functions can be valuable tools for dissecting complex cellular processes. Peptidoglycan synthesis and degradation is a process in bacteria that involves multiple enzymes under strict temporal and spatial regulation. We used a set of small molecules that inhibit the transglycosylation step of peptidoglycan synthesis to discover genes that help to regulate this process. We identified a gene responsible for the susceptibility of Escherichia coli cells to killing by glycolipid derivatives of vancomycin, thus establishing a genetic basis for activity differences between these compounds and vancomycin. |
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