Syntheses, antifeedant activity, and QSAR analysis of new oxa(thia)diazolyl 3(2H)-pyridazinones |
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Authors: | Cao Song Wei Na Zhao Chuanmeng Li Lina Huang Qingchun Qian Xuhong |
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Affiliation: | Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, P.O. Box 544, 130 Meilong Road, Shanghai 200237, China. scao@ecust.edu.cn |
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Abstract: | Twenty-eight new oxa(thia)diazolyl 3(2H)-pyridazinone derivatives were synthesized. Some compounds showed good chronic growth activities against the armyworm, Pseudaletia separata (Walker). Their EC50 values were determined in vivo. Nineteen 2-tert-butyl-4-chloro-5-[5'-aryl-2'-(1',3',4'-oxadiazolyl)methoxy]-3(2H)-pyridazinones were quantitatively analyzed using the QSAR procedure. The partial least squares method was applied to find relationships between activity and the physicochemical data. The results showed that dipole moment, molar refractivity, and log P are identified as critical parameters for chronic growth effects. |
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