Methylthio-Aspochalasins from a Marine-Derived Fungus Aspergillus sp. |
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| Authors: | Ying Liu Shizhe Zhao Wanjing Ding Pinmei Wang Xianwen Yang Jinzhong Xu |
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| Affiliation: | 1.Institute of Marine Biology, Ocean College, Zhejiang University, Hangzhou 310058, China; E-Mails: (Y.L.); (S.Z.); (W.D.); (P.W.);2.CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; E-Mail: |
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| Abstract: | Two novel aspochalasins, 20-β-methylthio-aspochalsin Q (named as aspochalasin V), (1) and aspochalasin W (2), were isolated from culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were determined on the basis of NMR and mass spectral data analysis. This is the first report about methylthio-substituted aspochalasin derivatives. Cytotoxicity against the prostate cancer PC3 cell line and HCT116 cell line was assayed using the MTT method. Apochalasin V showed moderate activity at IC50 values of 30.4 and 39.2 μM, respectively. |
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| Keywords: | gut fungi Aspergillus sp. aspochalasin methylthiol cytotoxicity |
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