Anti-Hebbian long-term potentiation in the hippocampal feedback inhibitory circuit |
| |
Authors: | Lamsa Karri P Heeroma Joost H Somogyi Peter Rusakov Dmitri A Kullmann Dimitri M |
| |
Institution: | Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. |
| |
Abstract: | Long-term potentiation (LTP), which approximates Hebb's postulate of associative learning, typically requires depolarization-dependent glutamate receptors of the NMDA (N-methyl-D-aspartate) subtype. However, in some neurons, LTP depends instead on calcium-permeable AMPA-type receptors. This is paradoxical because intracellular polyamines block such receptors during depolarization. We report that LTP at synapses on hippocampal interneurons mediating feedback inhibition is "anti-Hebbian":Itis induced by presynaptic activity but prevented by postsynaptic depolarization. Anti-Hebbian LTP may occur in interneurons that are silent during periods of intense pyramidal cell firing, such as sharp waves, and lead to their altered activation during theta activity. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|