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Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
Authors:Carlton Jane M  Hirt Robert P  Silva Joana C  Delcher Arthur L  Schatz Michael  Zhao Qi  Wortman Jennifer R  Bidwell Shelby L  Alsmark U Cecilia M  Besteiro Sébastien  Sicheritz-Ponten Thomas  Noel Christophe J  Dacks Joel B  Foster Peter G  Simillion Cedric  Van de Peer Yves  Miranda-Saavedra Diego  Barton Geoffrey J  Westrop Gareth D  Müller Sylke  Dessi Daniele  Fiori Pier Luigi  Ren Qinghu  Paulsen Ian  Zhang Hanbang  Bastida-Corcuera Felix D  Simoes-Barbosa Augusto  Brown Mark T  Hayes Richard D  Mukherjee Mandira  Okumura Cheryl Y  Schneider Rachel  Smith Alias J  Vanacova Stepanka  Villalvazo Maria  Haas Brian J
Institution:Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA. jane.carlton@med.nyu.edu
Abstract:We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the approximately 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.
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