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Formylmethionine codon AUG as an initiator of polypeptide synthesis |
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| Authors: | R E Thach K F Dewey J C Brown P Doty |
| Abstract: | Oligonucleotide messengers containing the sequence AUG at or near the 5' end of the chain stimulate the incorporation of N-formylmethionine,but not of free (unformylated) methionine. AUG is considerably more active in this regard than UUG, the other N-formylmethionine codon. The coding activity of subsequent in-phase triplets in the 3' direction from AUG is markedly stimulated by this codon. |
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