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Two New Jaspamide Derivatives from the Marine Sponge Jaspis splendens
Authors:Sherif S Ebada  Victor Wray  Nicole J de Voogd  Zhiwei Deng  Wenhan Lin  Peter Proksch
Abstract:Two new jaspamide derivatives 2 and 3, together with the parent compound jaspamide (1) have been isolated from the marine sponge Jaspis splendens collected in Kalimantan (Indonesia). The structures of the new compounds were unambiguously elucidated based on 1D and 2D NMR spectral data, mass spectrometry and comparison with jaspamide (1). The new derivatives inhibited the growth of mouse lymphoma (L5178Y) cell line in vitro with IC50 values of <0.1 μg/mL.
Keywords:Jaspis splendens  jaspamide Q and R  structure elucidation  cytotoxic activity
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