Marine-Derived Metabolites of S-Adenosylmethionine as Templates for New Anti-Infectives |
| |
| Authors: | Janice R. Sufrin Steven Finckbeiner Colin M. Oliver |
| |
| Affiliation: | Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York, NY, USA; E-Mails: (S.F.); (C.O.) |
| |
| Abstract: | S-Adenosylmethionine (AdoMet) is a key biochemical co-factor whose proximate metabolites include methylated macromolecules (e.g., nucleic acids, proteins, phospholipids), methylated small molecules (e.g., sterols, biogenic amines), polyamines (e.g., spermidine, spermine), ethylene, and N-acyl-homoserine lactones. Marine organisms produce numerous AdoMet metabolites whose novel structures can be regarded as lead compounds for anti-infective drug design. |
| |
| Keywords: | adenosylmethionine ethylene polyamines radical SAM quorum sensing |
|
|
