1,5-Diazacyclohenicosane,a New Cytotoxic Metabolite from the Marine Sponge Mycale sp |
| |
| Authors: | Laura Coello María Jesús Martín Fernando Reyes |
| |
| Affiliation: | Medicinal Chemistry Department, PharmaMar S.A.U., Pol. Ind. La Mina Norte, Avda de los Reyes 1, 28770-Colmenar Viejo (Madrid). Spain; E-Mails: (L.C.); (M.J.M.) |
| |
| Abstract: | A new cyclic diamine, 1,5-diazacyclohenicosane (1), was isolated from samples of the marine sponge Mycale sp. collected at Lamu Island (Kenya). Its structure was determined by a combination of spectroscopic techniques, including (+)-HRESIMS and 1D and 2D NMR spectroscopy. The compound displayed cytotoxicity at the μM level against three human tumor cell lines. |
| |
| Keywords: | marine sponges alkaloids cytotoxicity Mycale sp |
|
|
