Reflections on viruses and cancer |
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Authors: | C Darcel |
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Institution: | (1) Palliser Animal Health Laboratories Ltd, Box 1327, T1J 4K1 Lethbridge, Alberta, Canada |
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Abstract: | In recent years human and animal cancers have increasingly been shown to have a viral component in their aetiology. Oncogenic viruses will continue to be discovered although with certain cancers there is also an important environmental component, and with others — congenital cancers and cancers of early childhood — an important genetic component. There is thus the probability that cancer may not be an entity. Rather it may be a syndrome, the phenotypic expression of alteration of cellular metabolism, differentiation and cell death. More information is needed on the mathematics of cell division and destruction,in vivo andin vitro, and the involvement of biological clocks , i.e. ageing processes. These data, when available, should help us to understand better the nature of cancer and lead us to more effective methods of prevention and cure.Abbreviations AIDS
acquired immunodeficiency syndrome
- ALV
avian leukosis virus
- COFAL
complement-fixation test for avian leukosis viruses
- FeLV
feline leukaemia virus
- kb
kilobases
- L/S viruses
leukosis/sarcoma viruses
- MMTV
mouse mammary tumour virus
- MuLV
mouse leukaemia virus
- wt
wild type |
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Keywords: | aetiology cancer oncogene vaccination virus |
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