Progress in association of RSK2 with malignancies and its inhibitors |
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| Authors: | CHEN Kang-xing WANG Zi-you HUANG Yan-xia ZHONG Cheng-zhi LI Kai-heng HUANG Zun-nan |
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| Affiliation: | 1. The Second Clinical Medical College, Guangdong Medical University, Dongguan 523808, China;2. China-American Cancer Research Institute, Guangdong Medical University, Dongguan 523808, China;3. School of Public Health, Guangdong Medical University, Dongguan 523808, China. |
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| Abstract: | Ribosomal S6 kinase 2 (RSK2) is a member of the p90Rsk, which belongs to Ser/Thr kinase family. It is a downstream molecule of Ras/MAPK cascade and regulates a variety of cellular processes. RSK2 plays a key role in the cell proliferation, survival and transformation. Furthermore, the aberrant up-regulation of RSK2 was observed in different malignancies. We here briefly review the structure and function of RSK2, the relationship between RSK2 and tumor, and the existing RSK2 inhibitors. |
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| Keywords: | Ribosomal S6 kinase 2 Structure Function Tumor Inhibitors |
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