Research Progress on Regulation Factors of Myogenic Regulatory Factors and Myogenesis

Myogenic regulatory factors (MRFs) are important genes controlling myogenesis,including MyoD,MyoG,Myf5 and Myf6.MyoD is able to convert nonmyogenic fibroblast cells into myogenic cells,being a master regulatory gene in the process of muscle specified transcription;MyoG can control the start of myoblasts fusion,and induce myoblasts proliferation;Myf5 works in coordination with MyoD in regulating myogenesis,and Myf6 cooperates with MyoG to control myoblast determination.Studies indicate that the expression profiles of MRFs are closely related to meat production and meat quality in meat-type livestock,and the gene activity can be significantly affected by genetic,nutrition and environment.This article reviewed that the structure,function,expression profile and activity regulation of MRFs and the extrinsic regulation functions of nutrition,light,temperature,exercise and active factors on the gene activity of MRFs and myogenesis,aiming to provide the theory basis for manipulating the muscle development of animals.