Clinicopathological significance of pEZRThr567 expression in lung squamous carcinoma |
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Authors: | ZHANG Yuan JIN Cheng-long WANG Shen-tong YANG Yang LIN Zhen-hua JIN Tie-feng |
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Institution: | 1. Cancer Research Center, Yanbian University, Yanji 133002, China;
2. Department of Dermatology, Affiliated Hospital, Yanbian University, Yanji 133002, China |
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Abstract: | AIM: To investigate the clinicopathological significance of the protein expression of phosphorylated ezrin at threonine 567 (pEZRThr567) in lung squamous cell carcinoma, adjacent tissues and normal tissues. METHODS: pEZRThr567 protein was detected in lung squamous carcinoma, adjacent and normal tissues by the method of immunohistochemistry. The correlation of pEZRThr567 expression with clinicopathological parameters of lung squamous carcinomas was also analyzed. The localization of pEZRThr567 was detected by immunofluorescence staining in lung squamous cell line EBC-1. RESULTS: The protein expression of pEZRThr567 in lung squamous carcinoma was significantly higher than that in the adjacent and normal lung tissues (P<0.01). pEZRThr567 mainly localized on the cell membrane, and its over-expression signi-ficantly correlated with the differentiation, clinical stage and lymph node metastasis in lung squamous carcinoma. CONCLUSION: pEZRThr567 may be an effective biomarker for prediction of malignant potential and poor prognosis of lung cancer. |
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Keywords: | Lung squamous carcinoma Ezrin Immunohistochemistry |
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