Serum vascular endothelial growth factor in dogs with various proliferative diseases |
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Authors: | Hiro HORIKIRIZONO Kumiko ISHIGAKI Keigo IIZUKA Kei TAMURA Naoki SAKURAI Kazuyuki TERAI Tatsuya HEISHIMA Orie YOSHIDA Kazushi ASANO |
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Institution: | 1)Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Kanagawa, Japan;2)Present address: Department of Veterinary Radiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan |
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Abstract: | Angiogenesis plays an important role in the proliferation and metastasis mechanisms of malignant tumors. Vascular endothelial growth factor (VEGF), a group of cytokines that contribute to angiogenesis and vasculogenesis. This study aimed to investigate the serum VEGF-A concentrations in dogs with various proliferative diseases. A total of 202 dogs that were histopathologically diagnosed with proliferative diseases were included in the study. Serum VEGF-A concentrations were measured using enzyme-linked immunosorbent assay. Median serum VEGF-A concentrations in dogs were as follows: healthy dogs, 4 pg/ml 0–21 pg/ml]; hepatocellular carcinoma, 30 pg/ml 0–158 pg/ml, P=<0.001]; hepatocellular adenoma, 32 pg/ml 0–49 pg/ml, P=0.003]; hepatic nodular hyperplasia, 18 pg/ml 0–51 pg/ml, P=0.595]; adrenal pheochromocytoma, 32 pg/ml 0–187 pg/ml, P=<0.001]; adrenocortical carcinoma, 32 pg/ml 3–161 pg/ml, P=0.002]; adrenocortical adenoma, 27 pg/ml 0–106 pg/ml, P=0.005]; colorectal adenocarcinoma, 36 pg/ml 0–75 pg/ml, P=0.002]; colorectal adenoma, 43 pg/ml 0–48 pg/ml, P=0.144]; inflammatory colorectal polyps, 37 pg/ml 0–111 pg/ml, P=<0.001]; pulmonary adenocarcinoma, 35 pg/ml 4–107 pg/ml, P=0.002]; pulmonary histiocytic sarcoma, 35 pg/ml 0–131 pg/ml, P=0.016]; and follicular thyroid carcinoma, 35 pg/ml 0–106 pg/ml, P=0.009]. The serum VEGF-A concentrations were significantly higher in dogs with neoplastic lesions compared to healthy dogs, except for colorectal adenoma. High serum VEGF-A concentrations were observed in dogs with proliferative diseases. The present study suggests that angiogenesis-inhibiting therapy, which targets VEGF-A, may be useful for canine neoplastic diseases. |
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Keywords: | angiogenesis dog molecular-targeted therapy tumor vascular endothelial growth factor |
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