A case of feline temporal lobe epilepsy with hippocampal sclerosis and dentate gyrus malformation |
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| Authors: | James K CHAMBERS Shinya IWASAKI Shigeki IMAMOTO Yuya NAKAMOTO Kazuyuki UCHIDA |
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| Institution: | 1)Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan;2)Shinjo Animal Hospital, Nara, Japan;3)Neuro Vets Animal Neurology Clinic, Kyoto, Japan;4)Veterinary Medical Center, Osaka Prefecture University, Osaka, Japan |
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| Abstract: | A two-months-old, male, mixed breed cat presented with epileptic seizures. The cat was diagnosed with drug-resistant epilepsy, and died at 3-years of age. No gross lesion was found at necropsy. Histopathologically, the dentate gyrus granule cell layer of the hippocampus was irregularly arranged. Granule cells were dispersed and ectopic cells were sporadically observed in the molecular layer. The granule cells had an enlarged cytoplasm and swollen nucleus. Immunohistochemistry for NeuN and GFAP confirmed severe neuronal loss and mild gliosis in CA1. Binucleation and ischemic change were observed in the remaining pyramidal cells. This report describes a case of feline temporal lobe epilepsy and hippocampal sclerosis associated with dentate gyrus malformation. |
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| Keywords: | dentate gyrus malformation feline temporal lobe epilepsy hippocampal sclerosis histopathology immunohistochemistry |
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