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| 大肠杆菌热敏毒素研究概况 | |
| 引用本文： | 马兴元,赵玉军,郑文云,姜力,朱平. 大肠杆菌热敏毒素研究概况[J]. 动物医学进展, 2001, 22(2): 7-10 |
| 作者姓名： | 马兴元 赵玉军 郑文云 姜力 朱平 |
| 作者单位： | 1. 沈阳农业大学畜牧兽医学院; 2. 沈阳农业大学生物科技学院, 3. 中国人民解放军军需大学军事兽医研究所基因工程实验室, |
| 摘 要： | 本文在分析大肠杆菌热敏毒素（LT）生物学特性及其分子学水平研究的基础上，从蛋白质和基因水平阐述了猪源LT与人源LT的亲缘关系，评述了LT在研制人畜大肠杆菌腹泻疫苗中的应用价值，也通过对与LT具有相似蛋白和基因结构的霍乱毒素CT的分析，表明二者具有相同的进化起源，认为通过定点诱变的LT能够取代CT用作幽门螺杆菌疫苗的粘膜免疫佐剂。 |
| 关 键 词： | 大肠杆菌 热敏毒素 人畜腹泻疫苗 定点诱变 粘膜免疫佐剂 |
| 文章编号： | 1007-5038(2001)02-01-007-04 |
Research Situation of E.coli Heat-labile Enterotoxin |
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| MA Xin-yuan,ZHAO Yu-jun,ZHEN Wen-yun,JIANG Li,ZHU Ping. Research Situation of E.coli Heat-labile Enterotoxin[J]. Progress In Veterinary Medicine, 2001, 22(2): 7-10 | |
| Authors: | MA Xin-yuan ZHAO Yu-jun ZHEN Wen-yun JIANG Li ZHU Ping |
| Affiliation: | MA Xin yuan 1,ZHAO Yu jun 1,ZHEN Wen yun 2,JIANG Li 3,ZHU Ping 3 |
| Abstract: | On the basis of analysis and studies on molecular biological properties of E.coli heat labile enterotoxin (LT), author showed the relationship between P LT and H LT in the level of proteins and genes and evaluated the useful value of LT in the E.coli diarrhea vaccine to animals and mankind. In addition, by alayses of similarities structures of proteins and genes to LT and CT (cholera toxin), author revealled that CT and LT had the same evolutional origin, and considered that Site directed mutagenesis LT can substitute CT as a mucosal immunological adjuvant of Helicobacter pylori (Hp) quitely vaccine by genetic engineering. |
| Keywords: | LT E.coli diarrhea vaccine site directed mutagenesis mucosal immunological adjuvant |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |