New Cytotoxic Cytochalasans from a Plant-Associated Fungus Chaetomium globosum kz-19 |
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| Authors: | Tantan Li Yun Wang Li Li Mengyue Tang Qinghong Meng Cun Zhang Erbing Hua Yuehu Pei Yi Sun |
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| Institution: | 1.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; (T.L.); (Y.W.); (M.T.); (Q.M.); (C.Z.);2.College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China;3.School of Pharmacy, Harbin Medical University, Harbin 150081, China;4.Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; |
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| Abstract: | Four new cytochalasans, phychaetoglobins A–D (1–4), together with twelve known cytochalasans (5–16), were isolated from a mangrove-associated fungus Chaetomium globosum kz-19. The new structures were elucidated on the basis of extensive 1D and 2D NMR, HR ESIMS spectroscopic analyses, and electronic circular dichroism (ECD) calculations. The absolute configuration of 2 was established by application of Mosher’s method. Compounds 4–8 exhibited moderate cytotoxicities against A549 and HeLa cell lines with the IC50 values less than 20 μM. |
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| Keywords: | Chaetomium globosum kz-19 endophytic fungus cytochalasans cytotoxicity |
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