Multifaceted Clinical Effects of Echinochrome |
| |
| Authors: | Hyoung Kyu Kim Elena A. Vasileva Natalia P. Mishchenko Sergey A. Fedoreyev Jin Han |
| |
| Affiliation: | 1.Cardiovascular and Metabolic Disease Center, Smart Marine Therapeutic Center, Department of Physiology, College of Medicine, Inje University, Busan 57392, Korea;2.Department of Health Sciences and Technology, Graduate School of Inje University, Busan 57392, Korea;3.G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Prospect 100 let Vladivostoku, 159, 690022 Vladivostok, Russia; (E.A.V.); (N.P.M.); (S.A.F.) |
| |
| Abstract: | The marine drug histochrome is a special natural antioxidant. The active substance of the drug is echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone), the most abundant quinonoid pigment in sea urchins. The medicine is clinically used in cardiology and ophthalmology based on the unique properties of Ech A, which simultaneously block various links of free radical reactions. In the last decade, numerous studies have demonstrated the effectiveness of histochrome in various disease models without adverse effects. Here, we review the data on the various clinical effects and modes of action of Ech A in ophthalmic, cardiovascular, cerebrovascular, inflammatory, metabolic, and malignant diseases. |
| |
| Keywords: | histochrome echinochrome clinical effect |
|
|
