| 食管鳞状细胞癌中p53蛋白和PCNA表达与淋巴结转移的关系 |
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| 引用本文： | 林虹 黄应桂. 食管鳞状细胞癌中p53蛋白和PCNA表达与淋巴结转移的关系[J]. 湛江医学院学报, 2000, 18(1): 11-13 |
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| 作者姓名： | 林虹 黄应桂 |
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| 作者单位： | 广东医学院附属医院病理科!湛江524001 |
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| 摘 要： | 目的：探讨食管鳞状细胞癌ｐ５３蛋白及增殖细胞核抗原（ＰＣＮＡ）共同表达的意义。方法：应用免疫组化Ｓ－Ｐ法研究１０３例食管鳞状细胞癌ｐ５３蛋白和ＰＣＮＡ表达情况。结果：ｐ５３蛋白阳性率为６０．２％，ＰＣＮＡ高表达率为５５．３％；ｐ５３蛋白阳性、ＰＣＮＡ高表达均与淋巴结转移有关（Ｐ＝０．０２８７，Ｐ＝０．０００７）；当两者共同表达时，淋巴结转换率比其单表达者明显增高（Ｐ〈０．０１）。结论：ｐ５３和ＰＣ
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| 关 键 词： | 食管鳞状细胞癌 p53蛋白 PCNA 淋巴结转移 |
| 文章编号： | 1005-4057(2000)01-0011-03 |
| 修稿时间： | 1999-05-25 |
Expression of p53 proteins and PCNA in esophageal squamous cell carcinoma and its relationship with lymph node metastasis |
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| Lin Hong,Huang Yinggui,Cao Jun,et al. Expression of p53 proteins and PCNA in esophageal squamous cell carcinoma and its relationship with lymph node metastasis[J]. Journal of Guangdong Medical College, 2000, 18(1): 11-13 |
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| Authors: | Lin Hong Huang Yinggui Cao Jun et al |
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| Abstract: | Objective:To study significance of p53 proteins and PCNA coexpression in esophageal squamous cell carcinoma Methods:Using S P immunohistochemical methods,p53 and PCNA expressions in 103 cases of human esophageal carcinoma were studied Results:The positive rate of p53 proteins was 60 2%,The high expression rate of PCNA was 55 3% p53 protein expressions and PCNA high expression were related with the metastasis of lymph node( P=0 0287,P= 0 0007,respectively) When both p53 and PCNA were highly expressed,the lymph node metastasis rate significantly higher( P< 0 01)in comparison with other cases Conclusions:The results suggest that p53 may cooperate with PCNA,and examining the expression of p53 and PCNA together may be helpful to predicating the prognosis |
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| Keywords: | esophageal neoplasm p53 proteins PCNA immunohistochemistry |
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