Studies onEscherichia coli vaccines: Estimation of endotoxins in veterinary vaccines |
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| Authors: | S N Hussaini R A Ready |
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| Institution: | (1) Central Veterinary Laboratory, Ministry of Agriculture, Fisheries and Food, New Haw, Weybridge, Surrey, UK |
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| Abstract: | Fifteen batches ofE. coli vaccines for pigs, from three different manufacturers, were subjected to a quantitative form of the in vitro Limulusamoebocyte-lysate (LAL) test for their free endotoxin content. A batch of vaccine associated with abortions in pregnant sows was found to contain a much higher level of free endotoxin than batches of vaccine not associated with abortion. The evidence of these assays suggests that they will be useful in the quality control ofE. coli vaccines. |
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