| C型尿钠肽的作用机制及其对动物生殖调控的研究进展 |
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| 引用本文： | 荆天,字向东. C型尿钠肽的作用机制及其对动物生殖调控的研究进展[J]. 现代畜牧兽医, 2021, 0(1): 85-89 |
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| 作者姓名： | 荆天 字向东 |
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| 作者单位： | 西南民族大学动物科学国家民委重点试验室,四川成都610041 |
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| 基金项目： | 国家重点研发计划项目(2018YFD0502303);西南民族大学中央高校基本科研业务费平台建设项目(2020PTJS21001)。 |
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| 摘 要： | C型尿钠肽(CNP)属于尿钠肽家族,其结构较为保守,在各种动物体内分布广泛,主要通过自分泌和旁分泌方式发挥生物学作用.C型尿钠肽受体NPR-B通过第二信使cGMP传递信号.CNP在动物生殖中发挥重要作用.在雄性动物中,CNP通过CNP/NPR-B/cGMP级联效应调节精子活力、促进生殖细胞发育、对阴茎勃起具有调节作用;...
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| 关 键 词： | C型尿钠肽 动物繁殖 调控机制 |
The mechanism of C-type natriuretic peptide and its research progress in animal reproductive regulation |
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| Jing Tian,Zi Xiangdong. The mechanism of C-type natriuretic peptide and its research progress in animal reproductive regulation[J]. Modern JOurnal of Animal Husbandry and Veterinary Medicine, 2021, 0(1): 85-89 |
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| Authors: | Jing Tian Zi Xiangdong |
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| Affiliation: | (Key Laboratory of Animal Science of State Ethnic Affairs Commission,Southwest Minzu University,Sichuan Chengdu 610041) |
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| Abstract: | C-type natriuretic peptide(CNP) belongs to the natriuretic peptide family, which is conservative and widely distributed in various tissues of animals, acts predominantly by autocrine and paracrine secretion. Its receptor NPR-B transmits signals through the cGMP. CNP involved in various reproductive process. In male animals, CNP regulates sperm motility, promotes germ cell development and regulates male penile erection via CNP/NPR-B/cGMP cascade effect. In female animals, as an oocyte meiosis inhibitor, CNP promotes follicular development and increases the number of ovulations after gonadotropin stimulation. As the core inhibitor of biphasic in vitro prematuration system, CNP improved the in vitro maturation rate of oocytes prominently. The article reviews the structure, function and regulation mechanism of CNP. |
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| Keywords: | C-type natriuretic peptide Animal reproduction Regulation mechanism |
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