Congenital Cerebellar Cortical Degeneration in Holstein Cattle in Southern Brazil |
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Authors: | Schild A.L. Riet-Correa F. Portiansky E.L. Méndez M.C. Graça D.L. |
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Affiliation: | (1) Laboratório Regional de Diagnóstico, Faculdade de Veterinária, UFPel, Campus Universitário s/n, 96010-900 Pelotas, RS, Brazil;(2) Institute of Pathology, School of Veterinary Sciences, National University of La Plata, Calle 60 y 118, CC 296, (1900), La Plata, Buenos Aires, Argentina;(3) Department of Pathology, Santa Maria University, 97105-900 Santa Maria, RS, Brazil |
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Abstract: | A congenital progressive cerebellar disorder is described in Holstein calves. The clinical signs were progressive and were characterized by ataxia, hypermetria, a wide stance and fine head tremors. When the affected cattle were forced to run, the signs were exacerbated, leading to epileptiform attacks. Histological lesions consisted of a very selective cerebellar cortical degeneration, almost exclusively affecting the Purkinje cells. The disease affected 6 out of 200 Holstein calves from the same bull. However, results of mating tests of the bull with his daughters and granddaughters suggested that it was not hereditary (p = 0.0062) although an environmental–genetic interaction could not be ruled out. |
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Keywords: | cattle cerebellar degeneration cerebellum genetics histopathology neurology Purkinje cells |
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