BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF |
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Authors: | Thompson J S Bixler S A Qian F Vora K Scott M L Cachero T G Hession C Schneider P Sizing I D Mullen C Strauch K Zafari M Benjamin C D Tschopp J Browning J L Ambrose C |
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Affiliation: | Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA., The Institute of Biochemistry, University of Lausanne, CH-1066, Epalinges, Switzerland. |
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Abstract: | B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival. |
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