Type IV secretion and Brucella virulence |
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| Authors: | Maria Laura Boschiroli, Safia Ouahrani-Bettache, Vincent Foulongne, Sylvie Michaux-Charachon, Gisele Bourg, Annick Allardet-Servent, Chantal Cazevieille, Jean-Phillipe Lavigne, Jean Pierre Liautard, Michel Ramuz,David O&#x Callaghan |
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| Affiliation: | Maria Laura Boschiroli, Safia Ouahrani-Bettache, Vincent Foulongne, Sylvie Michaux-Charachon, Gisele Bourg, Annick Allardet-Servent, Chantal Cazevieille, Jean-Phillipe Lavigne, Jean Pierre Liautard, Michel Ramuz,David O’Callaghan, |
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| Abstract: | The type IV secretion system, encoded by the virB region, is a key virulence factor for Brucella. The 12 genes of the region form an operon that is specifically induced by phagosome acidification in cells after phagocytosis. We speculate that the system serves to secrete unknown effector molecules, which allow Brucella to pervert the host cell endosomal pathways and to create a novel intracellular compartment in which it can replicate. |
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| Keywords: | VirB TFSS VirB12 Quorum sensing Phagosome acidification Brucella |
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