The Tetrahydrofuran Motif in Polyketide Marine Drugs |
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| Authors: | Laura Ferná ndez-Peñ a,Carlos Dí ez-Poza,Paula Gonzá lez-André s,Asunció n Barbero |
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| Affiliation: | Department of Organic Chemistry, Campus Miguel Delibes, University of Valladolid, 47011 Valladolid, Spain; (L.F.-P.); (C.D.-P.); (P.G.-A.) |
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| Abstract: | Oxygen heterocycles are units that are abundant in a great number of marine natural products. Among them, marine polyketides containing tetrahydrofuran rings have attracted great attention within the scientific community due to their challenging structures and promising biological activities. An overview of the most important marine tetrahydrofuran polyketides, with a focused discussion on their isolation, structure determination, approaches to their total synthesis, and biological studies is provided. |
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| Keywords: | marine natural products oxygen heterocycles tetrahydrofuran total synthesis biological activity |
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