疾病的炎症本质及其中药干预

炎症是疾病的基本病理过程,与多种疾病的进程及转归相关。人类医学领域的炎症研究成果众多,而在兽医方面鲜有报道。因此,有必要从5方面对炎症及其中药干预进行综述:中药通过作用于炎症信号通路各环节,抑制或者阻断炎症信号传递,从而起到抑制炎症的作用;中药影响各种炎症因子的表达水平,改变炎症临床表现;中药通过抑制氧化产物生成,使炎症机体避免过氧化损伤;中药通过调节炎症平衡,从而影响炎症的发生与发展;中药通过适当调节炎症因子之间的相互关系,改善SIRS的产生与恶化。结合疾病与炎症的相关性以及中药在炎症干预方面的研究成果,综述炎症在各种疾病中的重要作用,为通过干预炎症、防制炎症相关疾病提供线索和依据。

Inflammatory Nature of Disease and Intervention by the Traditional Chinese Medicine

The inflammation is a primary pathological process involved in the progression and prognosis of various diseases. There are numerous studies on inflammation in the human medical field, but it is rarely reported in the field of veterinary. This article summarized recently reports about inflammation and the intervention of the traditional Chinese medicine (TCM) in five aspects:TCM inhibits the inflammation by suppressing or even blocking the transmission of inflammatory signals in each step of the signaling pathway.TCM influences the progression of inflammation by regulating the expression of various inflammatory cytokines.TCM protects cells from damage of peroxidation in the development of inflammation via inhibiting the formation of oxidation products.TCM influences the occurrence and development of inflammation by adjusting the inflammatory homeostasis.TCM prevents the occurrence and progression of SIRS by adjusting the interactions between inflammatory cytokines. Based on the correlation between diseases and inflammation, and the reports about the effect of TCM on inflammation, this article reviewed the significant role of inflammation in various diseases, and provided clue and evidence for the inflammatory intervention method by which to prevent and cure the diseases associated with inflammation.