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| SPRN转基因小鼠脏器质量和动物行为学的比较分析 | |
| 引用本文： | 王东旭,林超,万家余,潘朋朋,李莎,高宏伟. SPRN转基因小鼠脏器质量和动物行为学的比较分析[J]. 中国兽医学报, 2011, 31(4) |
| 作者姓名： | 王东旭 林超 万家余 潘朋朋 李莎 高宏伟 |
| 作者单位： | 1. 吉林大学畜牧兽医学院,吉林长春130062;军事医学科学院军事兽医研究所,吉林长春130062 2. 吉林大学畜牧兽医学院,吉林长春,130062 3. 军事医学科学院军事兽医研究所,吉林长春,130062 |
| 基金项目： | 国家自然科学基金资助项目(30972197,31072148) |
| 摘 要： | 采用统计学计算Tg(Mosprn-B)/C57BL/6转基因小鼠与C57BL/6野生型小鼠雌雄两性的主要脏器质量与系数,并利用水迷宫观察游泳路径及时间以探讨SPRN基因对小鼠生理结构、生长发育等影响。结果表明,相同年龄的Tg(Mosprn-B)/C57BL/6转基因小鼠,雄性的体质量及心、肺、肝、肾质量显著大于雌性(P<0.01),脑质量差异比较显著(P<0.05);比较脏器系数,脑和肝的差异比较显著(P<0.05)。与C57BL/6野生型小鼠相比较,Tg(Mosprn-B)/C57BL/6转基因小鼠脑更重(P<0.01);比较脏器系数发现,脑差异极显著(P<0.01),肺、肾、脾差异较显著(P<0.05)。水迷宫定位航行结果显示,Tg(Mosprn-B)/C57BL/6转基因小鼠的逃避潜伏期小于野生型小鼠,第4天的潜伏期具有显著差异性(P<0.05);在空间搜索试验中,Tg(Mosprn-B)/C57BL/6转基因小鼠第1次穿越平台时间小于C57BL/6野生型小鼠,穿越平台的次数大于C57BL/6野生型小鼠。 |
| 关 键 词： | 转基因小鼠 SPRN基因 脏器 水迷宫 行为学 |
Determination of weight of internal organs and observation of behavior in SPRN transgenic mice |
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| WANG Dong-xu,LIN Chao,WAN Jia-yu,PAN Peng-peng,LI Sha,GAO Hong-wei. Determination of weight of internal organs and observation of behavior in SPRN transgenic mice[J]. Chinese Journal of Veterinary Science, 2011, 31(4) | |
| Authors: | WANG Dong-xu LIN Chao WAN Jia-yu PAN Peng-peng LI Sha GAO Hong-wei |
| Affiliation: | WANG Dong-xu1,2,LIN Chao1,WAN Jia-yu2,PAN Peng-peng2,LI Sha2,GAO Hong-wei2*(1.College of Animal Science and Veterinary Medicine,Jilin University,Changchun 130062,China,2.The Military Veterinary Institute,Academy of Military Medical Sciences of PLA,China) |
| Abstract: | The weight and coefficient of internal organs of Tg(Mosprn-B)/C57BL/6 transgenic mice and C57BL/6 mice was obtained statistically.Then their swimming locus and time were observed in Morris water maze.Compared with female,in male,the weight of organs including heart,lung,liver,kidney showed very significant difference(P<0.01);the brain weight showed significant difference(P<0.05);the coefficient of brain and liver showed significant difference(P<0.05).Compared with C57BL/6 mice,in Tg(Mosprn-B)/C57BL/6 transg... |
| Keywords: | transgenic mice SPRN gene organ water maze behavior |
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