| 慢性乙型肝炎患者血清e抗原抗体系统与病情和预后关系的探讨 |
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| 引用本文： | 龙尧,陈明妃.慢性乙型肝炎患者血清e抗原抗体系统与病情和预后关系的探讨[J].湛江医学院学报,1993(3). |
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| 作者姓名： | 龙尧 陈明妃 |
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| 作者单位： | 广东医学院附属医院传染科
(龙尧)，广东医学院附属医院传染科(陈明妃) |
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| 摘 要： | 本文分析了114例慢性乙型肝炎(CHB)患者血清e抗原抗体系统与病情和预后的关系。结果表明,HBeAg阳性者大多数表现为慢性迁延性肝炎(CPH),而HBeAg(-)抗HBe(+)者较多表现为慢性活动性肝炎(CAH)、肝硬化、慢重肝或肝癌。抗-HBe(+)者的病情和预后较HBeAg(+)者严重(P<0.001)。抗-HBe(+)者可能为乙型肝炎病毒(HBV)前C区突变株感染所致。分析CHB患者血清e抗原抗体系统以及其它HBV标记物的特点,对估计其所感染的HBV类型、肝病轻重和预后好坏,可能具有重要的临床意义。
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| 关 键 词： | 慢性乙型肝炎 乙型肝炎e抗原 乙型肝炎e抗体 |
RELATIONSHIP OF SERUM HBeAg/ANTI-HBe SYSTEM TO THE SEVERITY OF DISEASE AND ITS PROGNOSIS IN PATIENTS WITH CHRONIC HEPATITIS B |
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| Long Yao Chen Minfei.RELATIONSHIP OF SERUM HBeAg/ANTI-HBe SYSTEM TO THE SEVERITY OF DISEASE AND ITS PROGNOSIS IN PATIENTS WITH CHRONIC HEPATITIS B[J].Journal of Guangdong Medical College,1993(3). |
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| Authors: | Long Yao Chen Minfei |
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| Institution: | Long Yao Chen Minfei
Department of Infectious Disease,The Affiliated Hospital |
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| Abstract: | Relationship of serum HBeAg/Anti-HBe system to the severity of disease and the prognosis in 114 patients with chronic hepatitis B was analyzed. Hepatitis B virus (HBV) makers were determined by radioimmunoassay. The results demonstrated that the majority of patients with serum HBeAg presented as chronic persistert hepatitis,but the undetected HBeAg patients
with positive serum anti-HBe occured more as chronic active hepatitis,cirrhosis of liver,
severe chronic hepatitis and hepatocellular carcinoma. Worse prognosis was observed in patients with serum anti-HBe. The patients with serum anti-HBe may be infected by HBV pre-C mutant. The results indicated that it may be of practical sigmificance to study the serum HBeAg/Anti-HBe system in order to estimate infected HBV type,severity of disease, and prognosis in patients with chronic hepatitis B. |
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| Keywords: | chronic hepatitis B hepatitis B e antigen hepatitis B e antibody |
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