岩藻糖胶对实验性糖尿病小鼠血糖影响的研究

用１０，５０，１５０及３００ｍｇ／ｋｇ岩藻糖胶给小鼠口服（灌胃），连续７ｄ，可使经四氧嘧啶诱发的高血糖小鼠血糖水平分别比阳性对照降低５４．２％，５７．１％，４３．３％及３６．９％。给已经四氧嘧啶形成的糖尿病小鼠注射１０ｋｇ／ｋｇ及５０ｍｇ／ｋｇ该糖胶后，其血糖水平分别为注射前的８０．４％和６０．６％，患病站鼠饮水量分别比阳性对照低约３６．２％及５０．６％，糖耐量明显改善，最佳作用时间在注射后４ｈ。

EFFECT OF FUCOIDIN ON BLOOD GLUCOSE IN ALLOXAN-INDUCED DIABETIC MICE

Fucoidin(FD),isolated from Laminaria japonica Aresch, administered per os 10,50,150,and 300mg/kg in advance for 7 d , made the blood glucose level in mice administered with alloxan decrease by 52.4%,57.1%,43.3%, and 36.9%,respectively,in comparison with the control. FD injecting 50mg/kg and 10mg/kg, made the blood glucose value of alloxaninduced diabetic mice drop to 60.6% and 80.4% respetively,in comparison to that before injected., and reduced waterintake by 50.6% and 36.2%, the optimum action time was the 4th hour or so after FD administration.;