| 复方中药多糖对体外脾淋巴细胞增殖、NO生成和蛋白激酶G的影响 |
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| 引用本文： | 张明. 复方中药多糖对体外脾淋巴细胞增殖、NO生成和蛋白激酶G的影响[J]. 动物医学进展, 2010, 31(9) |
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| 作者姓名： | 张明 |
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| 作者单位： | 菏泽学院生命科学系,山东菏泽,274015 |
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| 基金项目： | 山东省教育厅基金项目 |
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| 摘 要： | 将5种不同浓度复方中药多糖(CPPS)加入到小鼠脾淋巴细胞中培养48 h,观察CPPS对小鼠脾淋巴细胞增殖、对体外培养的脾淋巴细胞中NO的生成和蛋白激酶G(PKG)活性的影响。结果显示,CPPS能显著提高淋巴细胞增殖,显著升高细胞培养液中NO的生成,细胞内PKG活性明显提高,且CPPS、NO和PKG与淋巴细胞增殖有一定相关性。CPPS可能通过NO介导信号通路,引起第二信使环化鸟苷酸(cGMP)生成,从而提高PKG活性促进淋巴细胞的增殖,发挥其免疫调节作用。
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| 关 键 词： | 复方中药多糖 脾淋巴细胞增殖 一氧化氮 蛋白激酶G |
Effects of Compound Chinese Medicine Polysaccharides on Proliferation,NO Concentration and Protein Kinase G Activity in Lymphocyte |
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| ZHANG Ming. Effects of Compound Chinese Medicine Polysaccharides on Proliferation,NO Concentration and Protein Kinase G Activity in Lymphocyte[J]. Progress In Veterinary Medicine, 2010, 31(9) |
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| Authors: | ZHANG Ming |
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| Affiliation: | ZHANG Ming(Life Science Department,Heze College,Heze,Shandong,274015,China) |
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| Abstract: | The CPPS with five different concentrations was co cultured for 48 hour with splenic lymphocyte.The effects of CPPS on splenic lymphocyte proliferation,NO concentration and protein kinase G activity in vitro were observed.The results showed that the CPPS raised splenic lymphocyte proliferation,NO concentration and Protein kinase G activity significantly.In conclusion,the CPPS might perform its immunoregulation functions via signal transduction system in immunocytes by activating immunocytes to release NO an... |
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| Keywords: | compound Chinese medicine polysaccharide splenic lymphocyte proliferation NO protein kinase G |
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