Equine herpesvirus type 1 tegument protein VP22 is not essential for
pathogenicity in a hamster model,but is required for efficient viral growth in cultured
cells |
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| Authors: | Ayaka OKADA Satoko IZUME Kenji OHYA Hideto FUKUSHI |
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| Institution: | 1)Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan;2)Laboratory of Veterinary Microbiology, Faculty of Applied Biological Sciences, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan |
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| Abstract: | VP22 is a major tegument protein of Equine herpesvirus type 1 (EHV-1) that is a conserved
protein among alphaherpesviruses. However, the roles of VP22 differ among each virus, and
the roles of EHV-1 VP22 are still unclear. Here, we constructed an EHV-1 VP22 deletion
mutant and a revertant virus to clarify the role of VP22. We found that EHV-1 VP22 was
required for efficient viral growth in cultured cells, but not for virulence in a hamster
model. |
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| Keywords: | equine herpesvirus tegument protein VP22 |
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