Intracranial granular cell tumor in a dog |
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Authors: | Liu Chen-Hsuan Liu Chen-I Liang Sao-Ling Cheng Chiung-Hsiang Huang Sun-Chau Lee Chin-Cheng Hsu Wei-Chih Lin Yung-Chang |
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Institution: | Department of Veterinary Medicine, National Taiwan University, Taipei 106, Taiwan, ROC. |
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Abstract: | A 12-year-old female miniature poodle showed a 3-month history of neurological signs. Magnetic resonance imaging disclosed a high intensity tumor mass in the right cerebral hemisphere with compression of the lateral ventricle. At necropsy, a 2 x 3 cm white, friable mass was found in the right ventral pyriform lobe. Microscopically, the tumor cells were large, polygonal to round cells supported by a sparse fibrovascular stroma. The tumor cells typically possessed finely granular, pale eosinophilic cytoplasm with strongly positive periodic acid-Schiff (PAS) reaction. The tumor cells were immunopositive for vimentin, NSE and S-100. Ultrastructurally, the tumor cells showed large amounts of granules in the cytoplasm, and absence of basement membrane. Based on the above-mentioned findings, the intracranial granular cell tumor was diagnosed. |
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