Regulation of T cell homeostasis during fetal and early postnatal life |
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Authors: | Cunningham C P Cahill R N Washington E A Holder J E Twohig J P Kimpton W G |
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Affiliation: | Laboratory for Foetal and Neonatal Immunology, The University of Melbourne, Parkville, Vic., Australia. |
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Abstract: | Before parturition the fetal lamb develops a large pool of long-lived recirculating T cells which provides a large population of naive T cells with a diverse TcR repertoire. After birth and concomitant with exposure to environment antigens, fetal T cells are rapidly replaced by short-lived cells formed postnatally. The majority of thymic emigrants homing to spleen in postnatal lambs are short-lived, in contrast to emigrants targeting lymph nodes where a population appears to be long-lived. The lifespan of thymic emigrants in the fetus is unknown as in the relative importance of antigen-driven processes versus developmental programming in regulating T cell homeostasis in early postnatal life. |
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