Pharmacokinetics of pralidoxime in Bubalus bubalis |
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| Authors: | A K Srivastava J K Malik |
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| Affiliation: | 1. Department of Soil Science, Patuakhali Science and Technology University, Dumki, Patuakhali 8602, Bangladesh;2. Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan;1. Amity Institute of Wildlife Science, Noida 201303, Uttar Pradesh, India;2. Department of Biotechnology, AMIT College, Khurda 752057, Odisha, India;3. Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Ilsandong-gu, Gyeonggi-do 10326, Republic of Korea;4. Department of Food Science and Human Nutrition, Agricultural University of Athens, Athens, Greece;5. Department of Food Science and Biotechnology, Dongguk University, Ilsandong-gu, Goyang, Gyeonggi-do 10326, Republic of Korea |
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| Abstract: | Pharmacokinetics of pralidoxime (2-PAM) and its effect on blood enzymes were investigated in male buffalo calves following single intravenous administration (15 mg/kg). The distribution half-life, elimination half-life, apparent volume of distribution and total body clearance were 0·086 ± 0·001 h, 2·36 ± 0·09 h, 1 ± 0·05 l/kg and 296 ± 13 ml/h/kg, respectively. The drug plasma levels ⩾ 4 μg/ml were maintained up to 3 h. 2-PAM significantly elevated the serum carboxylesterase and lowered the serum levels of aspartate aminotransferase, alanine aminotransferase, acid phosphatase, alkaline phosphatase and lactate dehydrogenase. |
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