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Presumptive Baclofen Intoxication in a Dog
Authors:Daniel V. Hecht VMD  MS   Karin Allenspach DMV
Affiliation:*Resident in Emergency and Critical Care Medicine Department of Clinical Sciences Tufts University School of Veterinary Medicine;**Resident in Medicine Veterinary Hospital of the University of Pennsylvania
Abstract:A five year old mixed breed dog weighing 30 kg., presumptively ingested six to twelve 20 mg baclofen tablets four to six hours prior to admission. The dog had been ataxic and vocalizing at home but was stuporous on presentation. Toxic effects noted were hypothermia, hypertension and sedation, followed by prolonged agitation. Treatment consisted of administration of activated charcoal, fluid diuresis, sodium nitroprusside, and diazepam. Baclofen overdose has been reported frequently in humans, but this is the first report of it in a dog. (Vet Emerg & Crit Care, 1998; 8: 49–54)
Keywords:Baclofen    GABA    hypertension    agitation    intoxication    zero order kinetics
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