| 短链脂肪酸受体GPR41、GPR43的信号通路及生理功能 |
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| 引用本文： | 王永安,张春雷,王艳红,陈宏,房兴堂.短链脂肪酸受体GPR41、GPR43的信号通路及生理功能[J].中国牛业科学,2013(6):49-53. |
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| 作者姓名： | 王永安 张春雷 王艳红 陈宏 房兴堂 |
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| 作者单位： | 江苏师范大学细胞与分子生物学研究所,江苏徐州221116 |
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| 基金项目： | 由江苏省高校科研成果产业化推进工程项目（JHB2012-32）;徐州市科技计划项目（XF12C052）;国家自然科学基金（30972080,31101703）;国家现代肉牛牦牛产业技术体系专项（No.CAR-38）;江苏高校优势学科建设工程资助项目 |
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| 摘 要： | 短链脂肪酸（short-chain fatty acids,SCFA）是动物一种重要的能量来源,同时它也是一种重要的信号分子,它的生理功能和作用机制一直以来倍受关注.研究表明,GPR41和GPR43是目前已发现的仅有的2种特异性短链脂肪酸受体.它们可以通过介导短链脂肪酸,通过MAPK的信号通路,在调节机体内脂肪形成和白细胞功能等生理过程以及在动物肠道对营养物质的吸收中发挥重要作用.本文就短链脂肪酸受体GPR41和GPR43的结构、分布、下游信号通路,及其介导SCFA生理功能的最新研究进展进行简要综述.
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| 关 键 词： | 短链脂肪酸 GPR41 GPR43 信号通路 |
Signal Pathway and Physiological Functions of Short Chain Fatty Acid Receptor GPR41 and GPR43 |
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| WANG Yong-an,ZHANG Chun-lei,WANG Yan-hong,CHEN Hong,FANG Xing-tang.Signal Pathway and Physiological Functions of Short Chain Fatty Acid Receptor GPR41 and GPR43[J].China Cattle Science,2013(6):49-53. |
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| Authors: | WANG Yong-an ZHANG Chun-lei WANG Yan-hong CHEN Hong FANG Xing-tang |
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| Institution: | ( Institute of Cellular and Molecular Biology, Xuzhou Normal University, Xuzhou 221116, China) |
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| Abstract: | Short-chain fatty acids（SCFA）,as an important energy source for animals,are the key signal molecules whose physiological functions and mechanisms have drawn great attention for a long time. Many studies had shown that the GPR41 and GPR43 proteins were the only two receptor specificity of SCFA. They could be mediated through SCFA,through the MAPK signal pathway,in regulating the body fat for- mation, function of white blood cells and physiological process in the animal gut playing an important role in the absorption of nutrients. This article reviewed the structures, tissue distribution, ligand selectivity and downstream signal passage of SCFA,GPR41 and GPR43 as well as the latest progress of the mediated physiological functions of SCFA. |
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| Keywords: | Short-chain fatty acids （SCFA） GPR41 GPR43 signaling pathway |
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