The effect of a single intramammary infusion of a biological response modifier in cows at drying off |
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Authors: | Bibiana Elisabet Dallard H H Ortega I A Iguzquiza N R Salvetti O A Quaino L F Calvinho |
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Institution: | 1.Facultad de Ciencias Veterinarias,Universidad Nacional del Litoral,Rvdo. Padre Kreder 2805, (3080), Esperanza,Santa Fe,Argentina;2.Argentine National Research Council (CONICET),Buenos Aires,Argentina;3.Estación Experimental Agropecuaria Rafaela, Instituto Nacional de Tecnología Agropecuaria,Santa Fe,Argentina |
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Abstract: | Biological response modifiers (BRM) are compounds that interact with the immune system to regulate specific aspects of host
response. The objective of this study was to describe clinical and morphological changes during involution of bovine mammary
gland following a single-dose infusion of a BRM containing lipopolysaccharide and cellular fractions of Escherichia coli incorporated into liposomes. A massive leukocyte response and increased subepithelial stroma infiltration of mononuclear
cells, eosinophils and mast cells was observed in BRM-treated quarters compared with untreated controls; however, morphologic
parameters assessed at 11 days post infusion were indicative of only slightly accelerated involution compared with untreated
controls. In addition, BRM infusion at the end of lactation did not interfere with mammary epithelial cell proliferation and
caused only mild systemic effects. |
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