Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1 |
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| Authors: | Agrawal Nishant Frederick Mitchell J Pickering Curtis R Bettegowda Chetan Chang Kyle Li Ryan J Fakhry Carole Xie Tong-Xin Zhang Jiexin Wang Jing Zhang Nianxiang El-Naggar Adel K Jasser Samar A Weinstein John N Treviño Lisa Drummond Jennifer A Muzny Donna M Wu Yuanqing Wood Laura D Hruban Ralph H Westra William H Koch Wayne M Califano Joseph A Gibbs Richard A Sidransky David Vogelstein Bert Velculescu Victor E Papadopoulos Nickolas Wheeler David A Kinzler Kenneth W Myers Jeffrey N |
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| Institution: | Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA. nagrawal@jhmi.edu |
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| Abstract: | Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. To explore the genetic origins of this cancer, we used whole-exome sequencing and gene copy number analyses to study 32 primary tumors. Tumors from patients with a history of tobacco use had more mutations than did tumors from patients who did not use tobacco, and tumors that were negative for human papillomavirus (HPV) had more mutations than did HPV-positive tumors. Six of the genes that were mutated in multiple tumors were assessed in up to 88 additional HNSCCs. In addition to previously described mutations in TP53, CDKN2A, PIK3CA, and HRAS, we identified mutations in FBXW7 and NOTCH1. Nearly 40% of the 28 mutations identified in NOTCH1 were predicted to truncate the gene product, suggesting that NOTCH1 may function as a tumor suppressor gene rather than an oncogene in this tumor type. |
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