Antimicrobial and cytotoxic assessment of marine cyanobacteria - Synechocystis and Synechococcus |
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Authors: | Martins R F Ramos M F Herfindal L Sousa J A Skaerven K Vasconcelos V M |
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Affiliation: | 1.Departamento de Zoologia e Antropologia Dr. Augusto Nobre, Faculdade de Ciências, Praça Gomes Teixeira, 4099-002 Porto, Portugal;2.Centro Interdisciplinar de Investigação Marinha e Ambiental, Rua dos Bragas 289, 4050-123 Porto, Portugal;3.Escola Superior de Tecnologia da Saúde do Porto, Rua João de Oliveira Ramos, 874000-294 Porto, Portugal;4.Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N-5009 Bergen, Norway |
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Abstract: | Aqueous extracts and organic solvent extracts of isolated marine cyanobacteria strains were tested for antimicrobial activity against a fungus, Gram-positive and Gram-negative bacteria and for cytotoxic activity against primary rat hepatocytes and HL-60 cells. Antimicrobial activity was based on the agar diffusion assay. Cytotoxic activity was measured by apoptotic cell death scored by cell surface evaluation and nuclear morphology. A high percentage of apoptotic cells were observed for HL-60 cells when treated with cyanobacterial organic extracts. Slight apoptotic effects were observed in primary rat hepatocytes when exposed to aqueous cyanobacterial extracts. Nine cyanobacteria strains were found to have antibiotic activity against two Gram-positive bacteria, Clavibacter michiganensis subsp. insidiosum and Cellulomonas uda. No inhibitory effects were found against the fungus Candida albicans and Gram-negative bacteria. Marine Synechocystis and Synechococcus extracts induce apoptosis in eukaryotic cells and cause inhibition of Gram-positive bacteria. The different activity in different extracts suggests different compounds with different polarities. |
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Keywords: | MarineCyanobacteria Antibiotic Cytotoxic Synechocystis Synechococcus |
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