The chemistry and biological activity of a new class of azole fungicides: 1-amino-1,2,4-triazoles

The fungicidal activity of a novel class of triazole compounds in which the 1-position of the azole nucleus is bonded to a nitrogen atom was investigated. Such 1-amino-1,2,4-triazoles are amenable to great structural variation which allows the elucidation of the requirements for biological activity. As in most other triazole fungicides, the basic structural requirement for activity is a two-atom bridge connecting the azole nucleus to a hydrophobic group, typically an aromatic ring. The synthesis and optimization of fungicidal activity of this class of triazole fungicide are discussed.