Detection of cell membrane proteins that interact with virulent infectious bursal disease virus |
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| Authors: | Setiyono A Hayashi T Yamaguchi T Fukushi H Hirai K |
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| Institution: | Department of Veterinary Microbiology, Faculty of Agriculture, Gifu University, Japan. |
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| Abstract: | To detect the molecules that interact with infectious bursal disease virus (IBDV), the chicken B lymphoblastoid cell line, LSCC-BK3, which is permissive for virulent IBDV infection was investigated. The sodium dodecyl sulfate-solubilized plasma membrane fraction from the cells was subjected to a virus overlay protein binding assay. The IBDV specifically bound to proteins in LSCC-BK3 plasma membranes with molecular weights of 70, 82 and 110 kDa. This is the first report to demonstrate cellular molecules that interact with virulent IBDV. |
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