Pancreatic duct obstruction in the pig: electron microscopy of chronic pancreatitis |
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| Authors: | T Rahko H Saloniemi T V Kalima |
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| Institution: | The Department of Pathology and Livestock Hygiene, College of Veterinary Medicine and The Second Department of Surgery, University of Helsinki, PL 6, SF-00551 Helsinki, Finland |
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| Abstract: | Ultrastructural alterations of pancreatic tissues in growing pigs caused by surgical ligation of the main pancreatic duct are described. Five animals aged 6 to 7 weeks were operated on and necropsied 2, 6 or 8 weeks later. In addition, 3 pigs that were sham-operated served as controls. Obstruction of the ducts caused progressive luminal dilatations and rupture of intercellular connections of the epithelium followed by destruction and atrophy of acinar parenchyma and proliferations of immature ductular epithelial cells free from zymogen granules. |
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| Keywords: | pancreatic duct ligation exocrine pancreatic insufficiency experimental chronic pancreatitis porcine pancreas diseases |
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