Memory extinction, learning anew, and learning the new: dissociations in the molecular machinery of learning in cortex |
| |
Authors: | Berman D E Dudai Y |
| |
Institution: | Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel. |
| |
Abstract: | The rat insular cortex (IC) subserves the memory of conditioned taste aversion (CTA), in which a taste is associated with malaise. When the conditioned taste is unfamiliar, formation of long-term CTA memory depends on muscarinic and beta-adrenergic receptors, mitogen-activated protein kinase (MAPK), and protein synthesis. We show that extinction of CTA memory is also dependent on protein synthesis and beta-adrenergic receptors in the IC, but independent of muscarinic receptors and MAPK. This resembles the molecular signature of the formation of long-term memory of CTA to a familiar taste. Thus, memory extinction shares molecular mechanisms with learning, but the mechanisms of learning anew differ from those of learning the new. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|