心钠素在肉鸡腹水综合征发生发展中的作用

大群艾维菌商品代肉鸡从1日龄起用高能日粮常规饲养，以获得自然腹水综合征（ascites syndrome，AS）病例。应用放射免疫分析方法，分别测定了2～6周龄正常组、轻度腹水组、重度腹水组内鸡血浆和5周龄时心、肝、肺、肾等组织心钠素（atrial natriuretic polypeptide,ANP）的含量；用右心导管法测定了平均肺动脉压（mPAP），并用常规方法测定了腹水心脏指数（AHI），同时还对血浆ANP的含量与AHI、mPAP的相关性进行了分析。结果发现，随着日龄的增长，ANP的含量增加，AHI、mPAP也随着发生明显的变化；随腹水程度的加深，mPAP、AHI以及肉鸡血浆、组织ANP的含量均显著（P〈0．05）或极显著（P〈0．01）升高，组织中ANP的含量明显比血浆中的高；另外还发现，不同腹水程度肉鸡血浆ANP含量与5～6周龄时的mPAP、4～5周龄时的AHI相关性显著（P〈0．05）。结果表明，ANP参与了肉鸡AS的发生和发展过程并与肉鸡发生AS的程度有密切关系。

Effect of Atrial Natriuretic Polypeptide on the Formation and Development of Ascites Syndrome in Broilers

Natural AS broiler cases were got through using hyperalimentation dietary to feed a great deal of commercial broiler chickens from 1 day of age.Radioimmunoassay was used to detect atrial natriuretic polypeptide(ANP) of the normal,mild and severe ascites broiler groups in plasma at the age of 2 to 6 weeks and in tissues at the age of 5 weeks.The mPAP and AHI were measured as well.It was found that the AHI and mPAP in the mild ascites were higher or significantly higher than that of the normal group and the severe ascites group were higher or significantly higher than that of the mild ascites group.The level of ANP in plasma and tissues had the same tendency.The level of ANP in tissues was higher than that in plasma.Besides,there was significant positive correlation between plasma ANP and mPAP from 5 to 6 weeks of age,plasma ANP and AHI from 4 to 5 weeks of age.It is concluded that ANP must be able to take part in the formation and development of AS in broilers and play an important role in it.