Preliminary Results of Behavioral and Cardiopulmonary Effects of a Constant Rate Infusion of Remifentanil–Xylazine for Sedation in Horses |
| |
| Institution: | 1. Doctor, Department of Orthopaedics, Hamidiye Sisli Etfal Training and Research Hospital, Istanbul, Turkey;2. Associate Professor, Department of Orthopaedics, Hamidiye Sisli Etfal Training and Research Hospital, Istanbul, Turkey;1. Programa de Mestrado em Biociência Animal, Universidade de Cuiabá, Mato Grosso, Brazil;2. Laboratory of Animal Pathology, Faculty of Veterinary Medicine, Universidade de Cuiabá, Mato Grosso, Brazil;3. Department of Large Animal Production and Internal Medicine, Faculty of Veterinary Medicine, Universidade de Cuiabá, Mato Grosso, Brazil;4. Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Paraná, Brazil;1. Department of Anatomy, University of Veterinary Medicine Hannover, Hannover, Germany;2. Unit for Reproductive Medicine, Clinic for Horses, University of Veterinary Medicine Hannover, Hannover, Germany;3. Institute for Reproductive Biology, University of Veterinary Medicine Hannover, Hannover, Germany;4. Clinic for Swine, Small Ruminants, Forensic Medicine, and Ambulatory Service, University of Veterinary Medicine Hannover, Hannover, Germany;5. Institute for General Radiology and Medical Physics, University of Veterinary Medicine Hannover, Hannover, Germany;6. Tierärztliche Klinik für Pferde auf Boyenstein, Beckum, Germany;7. Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany;1. Department of Microbiology, Faculty of Veterinary Medicine, Mahanakorn University of Technology, Nong Chok, Bangkok, Thailand;2. Clinic for Horse, Faculty of Veterinary Medicine, Mahanakorn University of Technology, Nong Chok, Bangkok, Thailand;1. Department of Clinical Sciences, JT Vaughan Large Animal Teaching Hospital, College of Veterinary Medicine, Auburn University, Auburn, AL;2. Large Animal Hospital, UF College of Veterinary Medicine, Large Animal Clinical Sciences, Gainesville, FL |
| |
| Abstract: | Standing surgical procedures are performed commonly in horses under sedation. The use of a xylazine and remifentanil combination has not been investigated in horses. We proposed to evaluate behavioral and cardiopulmonary effects of an intravenous (IV) infusion of xylazine with remifentanil for sedation in horses. Xylazine (0.8 mg/kg IV) followed in 3 minutes by remifentanil (0.0005 mg/kg IV), and a constant rate infusion of xylazine and remifentanil (0.65 mg/kg/h; 0.0225 mg/kg/h, respectively) was administered in three horses. Heart rate, respiratory rate (RR), arterial blood pressures, quality of sedation, pH, partial pressure of arterial CO2 (PaCO2), partial pressure of arterial O2 (PaO2), ataxia, sedation, and sedation overall outcome were assessed. Heart rate and RR remained within normal values during sedation without significant changes from baseline. Systolic, mean, and diastolic arterial blood pressures were increased during sedation. There were no significant changes in pH, PaCO2, and PaO2. Sedation developed immediately after injection of xylazine in the three horses but did not increase after remifentanil bolus or IV infusion of both drugs. None of the mares had ataxia. Adverse effects during and after sedation were present: excitement, increase in locomotor activity, and decrease in the gastrointestinal motility. The combination of xylazine and remifentanil sedation protocol produces adverse effects. This protocol cannot be recommended for clinical conditions, at the described doses. |
| |
| Keywords: | Equine Remifentanil Standing equine surgery Opioids Standing sedation |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
